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NEO214 Is A Mediator of Cell Death Through The Death Receptor Pathway

March 18, 2019

The Rolipram–Perillyl Alcohol Conjugate (NEO214) Is A Mediator of Cell Death through the Death Receptor Pathway

Authors: Hee-Yeon Cho1,Thu Zan Thein1,WeijunWang1, StephenD. Swenson1, Rochelle A. Fayngor1, Mengting Ou2, Nagore I. Marín-Ramos1, Axel H. Sch€onthal3, Florence M. Hofman1,4, and Thomas C. Chen1,4

This publication shows how NEO214 has great therapeutic potential, especially for brain tumors as the drug can cross the blood-brain barrier, and is effective in the TRAIL-rich astrocyte microenvironment. NEO214 is a strong candidate for use in the treatment of GBMs.

1Department of Neurosurgery, Keck School of Medicine, University of Southern California, Los Angeles, California.2Key Laboratory of Biorheological Science and Technology, Ministry of Education, College of Bioengineering, Chongqing University, Chongqing, China3Department of Molecular Microbiology and Immunology, Keck School of Medicine, University of Southern California, Los Angeles, California4Department of Pathology, Keck School of Medicine, University of Southern California, Los Angeles, California.