Publications - NEO 212
Studying The Therapeutic Effect Of NEO 212 Nasopharyngeal Carcinoma
Therapeutic Effect Of TMZ-POH On Human Nasopharyngeal Carcinoma Depends On Reactive Oxygen Species Accumulation Authors: Li Xie1, Xingguo Song1, Wei Guo2, Xingwu Wang1, Ling Wei1, Yang Li1, Liyan Lv1, Weijun Wang3, Thomas C. Chen3, and Xianrang Song1 NeOnc...
NEO 212 Provides Better Effectiveness For Treatment of Metastatic Melanoma Containing MGMT Overexpression
A Novel Temozolomide Analog, NEO 212, Demonstrates Enhanced Activity Against MGMT-Positive Melanoma In Vitro and In Vivo. Authors: Thomas C. Chen1, Hee-Yeon Cho1, Weijun Wang1, Jenny Nguyen2, Niyati Jhaveri3, Rachel Rosenstein-Sisson3, Florance M. Hofman3, and Axel H....
NEO 212 Study Shows Increased Cytotoxicity for Temozolomide Resistant Glioma Tumor Cells
Initial Study Shows NEO 212 Temozolomide Conjugate As A Novel Drug For Effective Treatment of a Broad Range of Temozolomide-Resistant Gliomas. Authors: Hee-Yeon Cho1, Weijun Wang1, Niyati Jhaveri2, David Jungpa Lee2, Natasha Sharma4, Louois Dubeau2, Axel H....
NEO 212 Shows Efficacy In Treating Breast Cancer That Has Metastasized To The Brain
A Novel Temozolomide–Perillyl Alcohol Conjugate Exhibits Superior Activity against Breast Cancer Cells In Vitro and Intracranial Triple-Negative Tumor Growth In Vivo. Authors: Thomas C. Chen1,2, Hee-Yeon Cho1, Weijun Wang1, Manasai Barath3, Natasha Sharma4, Florance...
NEO 212 Study Shows Increased Efficacy For Treatment Of Brain Metastasized Breast Cancer
A Novel Temozolomide-Perillyl Alcohol Conjugate Exhibits Superior Activity Against Breast Cancer Cells In Vitro And Intracranial Triple-Negative Tumor Growth In Vivo Authors: Thomas C Chen1,2, Hee-Yeon Cho2, Weijun Wang1, Manasi Barath3, Natasha Sharma4, Florence M....
NEO 212 Preferentially Concentrates In Brain Tumor Tissue For Delivery Of TMZ
Pharmacokinetic Properties Of The Temozolomide Perillyl Alcohol Conjugate (NEO212) In Mice. Authors: Hee-Yeon Cho1, Steve Swenson1, Thu Zan Thein1, Weijun Wang1, Weijun Wang1, Neloni R. Wijeratne2, Nagore I. Marín-Ramos1, Jonathan E. Katz2, Florence M. Hofman1,4, Axel...