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POH Shows Remarkable Ability To Bypass The Blood Brain Barrier For Intranasal Delivery Of Therapeutics

February 3, 2019

Intranasal Perillyl Alcohol for Glioma Therapy: Molecular Mechanisms and Clinical Development

Authors: Thomas C. Chen1, Clovis O. da Fonseca2and Axel H. Schönthal3

This publication demonstrates how the natural compound perillyl alcohol (POH) shows a remarkable ability to circumventing the obstacle posed by the BBB to reach the brain via direct nose-to-brain transport.

1 Department of Neurological Surgery, Keck School of Medicine, University of Southern California, Los Angeles, CA 90089, USA 2 Department of General and Specialized Surgery, Antonio Pedro University Hospital, Fluminense Federal University, Niterói, RJ 24220, Brazil 3Department of Molecular Microbiology and Immunology, Keck School of Medicine, University of Southern California, Los Angeles, CA 90089, USA