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Pharmaceutical Compositions Comprising Monoterpenes
Patent Number: US 9,133,085 B2
Country Filed In: USA
Formulation: NEO 100


The present invention provides a process for purifying a monoterpene or sesquiterpene having a purity greater than about 98.5% (w/w). The process comprises the steps of derivatizing the monoterpene ( or sesquiterpene) to produce a monoterpene ( or sesquiterpene) derivative, separating the monoterpene ( or sesquiterpene) derivative, and releasing the monoterpene ( or sesquiterpene) from the derivative. Also encompassed by the scope of the present invention is a phar­maceutical composition comprising a monoterpene ( or ses­quiterpene) having a purity greater than about 98.5% (w/w). The purified monoterpene can be used to treat a disease such as cancer. The present monoterpene ( or sesquiterpene) may be administered alone, or may be co-administered with radia­tion or other therapeutic agents, such as chemotherapeutic agents.

The Formulation:

NEO 100 is a highly purified form of the natural compound Perillyl Alcohol (POH). POH is a natural substance isolated from the essential oils of lavender, peppermint, spearmint, cherries, celery seeds, and several other plants. Research evidence has shown that POH can interfere with the replication of dividing cells such as seen in cancer. POH has shown antitumor activity against a range of cancer types including pancreatic, lung, colon, and liver cancers in laboratory and animal studies and an inhaled form of POH has shown preliminary evidence of safety and effectiveness in patients with recurrent gliomas. NEO100 serves as the base component of each of NeOnc Technologies product line.