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Methods Of Treating Neurofibromatosis With Perillyl Alcohol
Patent Number: US 2022-0054481 Al
Country Filed In: USA
Formulation: NEO 100


The present methods treat neurofibromatosis by a adminis­tering to a subject perillyl alcohol or iso-perillyl alcohol. The present methods also treat neurofibromatosis by administer­ing to a subject a carbamate of perillyl alcohol, or a carbamate of iso-perillyl alcohol. The perillyl alcohol car­bamate may comprise perillyl alcohol conjugated with rolip­ram or temozolomide.

The Formulation:

NEO 100 is a highly purified form of the natural compound Perillyl Alcohol (POH). POH is a natural substance isolated from the essential oils of lavender, peppermint, spearmint, cherries, celery seeds, and several other plants. Research evidence has shown that POH can interfere with the replication of dividing cells such as seen in cancer. POH has shown antitumor activity against a range of cancer types including pancreatic, lung, colon, and liver cancers in laboratory and animal studies and an inhaled form of POH has shown preliminary evidence of safety and effectiveness in patients with recurrent gliomas. NEO100 serves as the base component of each of NeOnc Technologies product line.