NEO 412 Effectively Kills Melanoma Cells and Inhibits Tumor Growth
February 3, 2019
NEO 412: A temozolomide analog with transdermal activity in melanoma in vitro and in vivo
Authors: Steve Swenson1,Catalina Silva-Hirschberg2, Weijun Wang1, Anupam Singh2, Florence M. Hofman3, Kristen L. Chen4, Axel H. Schönthal2 and Thomas C. Chen1,3,5
This paper demonstrates how NEO 412 effectively killed melanoma cells In vitro, including TMZ-resistant and BRAF mutant ones, through DNA alkylation and subsequent apoptosis and In Vivo and how NEO 412 inhibited tumor growth when applied topically to the skin of tumor-bearing animals.
1Department of Neurosurgery, Keck School of Medicine, University of Southern California, Los Angeles, California.2Department of Molecular Microbiology & Immunology, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA, 3Department of Pathology, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA, 4Medical College of Wisconsin, Milwaukee, WI, USA, 5Department of Orthopedic Surgery, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA