NEO 412 Effectively Kills Melanoma Cells and Inhibits Tumor Growth

NEO 412: A temozolomide analog with transdermal activity in melanoma in vitro and in vivo

Authors: Steve Swenson¹,Catalina Silva-Hirschberg², Weijun Wang¹, Anupam Singh², Florence M. Hofman³, Kristen L. Chen⁴, Axel H. Schönthal² and Thomas C. Chen^1,3,5

This paper demonstrates how NEO 412 effectively killed melanoma cells In vitro, including TMZ-resistant and BRAF mutant ones, through DNA alkylation and subsequent apoptosis and In Vivo and how NEO 412 inhibited tumor growth when applied topically to the skin of tumor-bearing animals.

¹Department of Neurosurgery, Keck School of Medicine, University of Southern California, Los Angeles, California.²Department of Molecular Microbiology & Immunology, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA, ³Department of Pathology, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA, ⁴Medical College of Wisconsin, Milwaukee, WI, USA, ⁵Department of Orthopedic Surgery, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA