NEO 214 Is A Mediator of Cell Death Through The Death Receptor Pathway

The Rolipram–Perillyl Alcohol Conjugate (NEO214) Is A Mediator of Cell Death through the Death Receptor Pathway

Authors: Hee-Yeon Cho¹,Thu Zan Thein1,WeijunWang¹, StephenD. Swenson¹, Rochelle A. Fayngor¹, Mengting Ou², Nagore I. Marín-Ramos¹, Axel H. Sch€onthal³, Florence M. Hofman^1,4, and Thomas C. Chen^1,4

This publication shows how NEO214 has great therapeutic potential, especially for brain tumors as the drug can cross the blood-brain barrier, and is effective in the TRAIL-rich astrocyte microenvironment. NEO214 is a strong candidate for use in the treatment of GBMs.

¹Department of Neurosurgery, Keck School of Medicine, University of Southern California, Los Angeles, California.²Key Laboratory of Biorheological Science and Technology, Ministry of Education, College of Bioengineering, Chongqing University, Chongqing, China³Department of Molecular Microbiology and Immunology, Keck School of Medicine, University of Southern California, Los Angeles, California⁴Department of Pathology, Keck School of Medicine, University of Southern California, Los Angeles, California.