Independent Perillyl Alcohol Study Confirms Effectiveness As An Antitumoral Agent

Perillyl Alcohol And Its Synthetic Derivatives: The Rising Of A Novel Class Of Selective And Potent Antitumoral Compounds

Authors: Renato C. S. Lessa ¹, Aline C. C. A. Gomes²

In this independent study performed by Drs Lessa and Gomes, the viability of Perillyl Alcohol (POH) is examined in specific to its application as a potent treatment alternitive for difficut to treat tumor treatments in cases such as glioblastoma multiforme. The sutdy examines various derivitives and theri efficacy to reduce the invasiveness of TMZ resistant glioma cells.

The report concluded that the growing impact of POH in medicinal chemistry continuies to unveil its potential as a versatile scaffold for novel drugs development. The natural occurrence monoterpene has demonstrated promising effectivity in polychemotherapeutic approaches as a chemosensitizing agent, opening opportunities for more chemotherapeutic treatments with reduced drugs administered doses. In addition, outstanding results have been reported after molecular hybridization, expanding chemotherapy frontiers with promising quality potential drugs, especially for the challenging GBM treatment. Moreover, the new promising multitarget POH derivative drugs might allow administration protocols that are not limited to inhalation for GBM treatment, like topical administration for MM treatment. Lastly, it is notable that polarity sensibility, solubility and regioisomerism (when applicable) play a key role in overall hybrids cytotoxicity, making POH a challenging, but rewarding, lead compound for synthetic medicinal chemistry.

¹Departamento de Química Orgânica, Instituto de Química, Universidade Federal Fluminense, Campus do Valonguinho, Niterói, Rio de Janeiro 24020-150, Brazil, ²Departamento de Biologia Celular e Molecular, Instituto de Biologia, Universidade Federal Fluminense, Campus do Valonguinho, Niterói, Rio de Janeiro 24020-141, Brazil